My kids and I are having fun playing around learning to use Autodesk SketchBook Pro 2011. It uses the computer and mouse (no other special equipment) and the art tools range from things like paint, marker, pencil, and airbrush.
What amazes me is how my visual-spatial learner has an intuitive sense for using programs he knows nothing about; he's a real whiz at this already.
Disclosure: I received this product from Amazon Vine product review program. For my blog's full disclosure statement see the link at the top of my blog's sidebar.